Our Provisional Patent

Summary of the Invention

This invention introduces a high-potency skin cream containing 20% gingerol and up to 50% electrophilic compounds designed to activate NRF2 and AMPK pathways while inhibiting NF-κB. The formulation uses a specialized nanofiltration system to concentrate active ingredients from ginger juice, ensuring maximum efficacy.

Key Features

  • Active Ingredients:
    • Gingerol (20%): Extracted and concentrated to reduce oxidative stress and inflammation.
    • Electrophilic Compounds: Include curcumin, sulforaphane, and EGCG, targeting NRF2 activation with a redox potential under 0.8V.
  • Carrier Base:
    • Contains jojoba oil, glycerin, and ECOCERT-approved emulsifiers for skin compatibility and optimal absorption.
  • Advanced Extraction Technology:
    • A proprietary system removes 90% of water and impurities, concentrating gingerol and preserving bioactivity.

Mechanism of Action

  • NRF2 Activation:
    • Promotes antioxidant defense by increasing glutathione and superoxide dismutase levels.
    • Reduces oxidative stress and supports skin and muscle recovery.
  • AMPK Activation:
    • Enhances mitochondrial function, fatty acid oxidation, and cellular repair.

Benefits

  • Athletic Recovery: Decreases inflammation, improves energy production, and reduces muscle soreness.
  • Anti-Aging: Protects collagen and elastin, reduces oxidative stress, and delays cellular senescence.

Applications

  • Anti-Aging Cream: Promotes skin elasticity and resilience.
  • Recovery Cream: Enhances post-exercise muscle repair and energy restoration.

Experimental Validation

  • In Vitro: Demonstrated NRF2 and AMPK activation in cell cultures.
  • In Vivo: Improved skin elasticity and faster recovery reported in trials.

This innovation provides a dual-action solution for anti-aging and enhanced recovery, using cutting-edge extraction methods to deliver high efficacy.

Practical Implications for Endurance Athletes 

Designed to amplify the benefits of exercise, this cream helps athletes reduce damage, enhance repair, and boost long-term fitness gains. By targeting key pathways like NRF2 and AMPK, gingerol cream helps athletes recover faster, push harder, and achieve a much higher plateau in their training. Here’s how it works:

Effect on NRF2 Activation

  • Expected Increase: NRF2 activity could increase an additional 20-50% beyond exercise-induced levels.
  • Mechanism:
    • Gingerol binds to Keap1 cysteine residues, releasing NRF2 to activate antioxidant defenses.
    • Topical application enhances localized NRF2 activation in muscles, improving repair and resilience where oxidative stress is highest.
  • Localized Benefit: This heightened NRF2 response reduces oxidative damage and speeds recovery by bolstering mitochondrial and cellular defenses.

Effect on AMPK Activation

  • Expected Increase: AMPK activity might increase by 10-30%, depending on absorption and tissue penetration.
  • Mechanism:
    • Gingerol mildly disrupts mitochondrial efficiency, increasing the AMP/ATP ratio, which activates AMPK.
    • AMPK-driven processes like autophagy and mitochondrial biogenesis are enhanced, improving recovery and energy replenishment.
  • Localized Impact: Enhanced glucose uptake and fatty acid oxidation in treated muscles improve recovery and sustain energy.

Reduction of ROS Damage

  • Without Gingerol Cream:
    • Exercise-induced ROS damage affects lipids (40-60%), proteins (30-50%), and mtDNA (5-10%).
    • Natural antioxidant defenses neutralize ~50-70% of ROS, leaving ~30-50% of damage unrepaired.
  • With Gingerol Cream:
    • Increases NRF2 activity and antioxidant enzymes, neutralizing an additional 20-30% of ROS.
    • Lipid damage decreases by 20-30%, preserving cellular membranes.
    • Protein oxidation and mtDNA damage also reduce by 20-30%, protecting key cellular functions.

Improved Efficacy of Workouts

  • Without Cream:
    • Net Adaptation Efficiency: Moderate, with ~70-80% of effort contributing to positive adaptations.
    • Recovery Time: Standard, with slower repair and lingering damage.
  • With Cream:
    • Net Adaptation Efficiency: High, with ~90-95% of effort translating into fitness gains.
    • Recovery Time: Faster, enabling quicker returns to high-intensity training.
    • Enhanced Performance: Reduced damage and amplified repair improve mitochondrial efficiency, muscle endurance, and overall resilience.

Delaying and Breaking Through Plateaus

  • Plateaus Explained:
    • Fitness plateaus occur when workout-induced damage equals the body’s repair capacity.
    • As fitness improves, adaptation slows, requiring interventions like optimized recovery or novel training stimuli.
  • How Gingerol Cream Helps:
    • Reduces ROS damage and amplifies repair, shifting the balance in favor of continued adaptation.
    • Supports faster recovery, allowing for higher training loads or increased intensity.

Conclusion

Gingerol cream enhances workout efficacy by reducing oxidative damage and boosting repair mechanisms. This allows you to break through plateaus and reach a much higher level of fitness. By improving recovery, supporting resilience, and maximizing adaptation, gingerol cream empowers you to achieve your best performance and sustain it over time. Whether you’re aiming for greater endurance, strength, or overall fitness, gingerol cream is a game-changer for athletes looking to optimize their training.